M. lignano Neoblast Screen 2016.
Mlig455 transcriptome version. Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano. (2016) Grudniewska M*, Mouton S*, Simanov S, Beltman F, Grelling M, de Mulder K, Arindrarto W, Weissert P, van der Elst S, Berezikov E. eLife 2016;5:e20607. Home Download

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Transcript classification

Neoblast, stringent 218 transcrip clusters obtained by overllaping 'Irradiation' and 'Neoblast' categories
Neoblast 508 transcript clusters enriched in proliferating cells excluding germline
S/G2/M, no gonads 517 transcript clusters enriched in late-S/G2/M cells in all conditions, including intact animals, cut heads and juveniles
Germline 1,884 transcripts enriched in proliferating germline cells
Int S/G2/M 4,932 transcript clusters significantly enriched in late-S/G2/M cells of intact animals
Irradiation 4,469 transcript clusters significantly depleted at all three time points after irradiation (0h vs 12h, 0h vs 24h, 0h vs 72h)

This is the updated analysis based on Mlig_RNA_4_5_v4 transcriptome assembly.

(The numbers on the images are still from the original analysis)

Irradiation timecourse

FACS-based analysis

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